Author

J. Pitts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2 Pharmacology & Toxicology· 2 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Organism:non-human primate· 2 Organism:Arabidopsis· 1 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. P. Bilello· 4 shared J. Y. Feng· 4 shared T. Cihlar· 4 shared J. K. Perry· 3 shared V. Du Pont· 3 shared X. Lu· 3 shared B. Ma· 2 shared D. Babusis· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

J. P. Bilello

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

C. J. Gordon, S. M. Walker, E. P. Tchesnokov, D. Kocincova, J. Pitts, D. S. Siegel, J. K. Perry, J. Y. Feng, J. P. Bilello, M. Gotte

This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.

bioRxiv · Apr 22, 2024Biochemistry

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

D. S. Siegel, H. C. Hui, J. Pitts, M. S. Vermillion, K. Ishida, D. Rautiola, M. Keeney, H. Irshad, L. Zhang, K. Chun, G. Chin, B. Goyal, E. Doerffler, H. Yang, M. O. Clarke, , R. L. Mackman

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

bioRxiv · Apr 17, 2024 · PreprintBiochemistry

A conserved odorant receptor underpins borneol-mediated repellency in culicine mosquitoes

Y. Vainer, Y. Wang, R. M. Huff, D. Perets, E. Sar-Shalom, E. Yakir, M. Ghaninia, I. V. Coutinho-Abreu, C. Ruiz, D. Rajamanickam, A. Warburg, O. Akbari, P. A. Papathanos, R. Ignell, J. A. Riffell, , J. D. Bohbot

This study identifies a conserved odorant receptor involved in borneol-mediated repellency in culicine mosquitoes by mapping the neural pathway activated by borneol.

bioRxiv · Aug 1, 2023 · PreprintEvolutionary Biology

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

R. L. Mackman, R. Kalla, D. Babusis, J. Pitts, K. T. Barrett, K. Chun, V. Du Pont, L. Rodriguez, J. Moshiri, Y. Xu, M. Lee, G. Lee, B. Bleier, A.-Q. Nguyen, B. M. O'Keefe, , T. Cihlar

bioRxiv · Apr 28, 2023Pharmacology & Toxicology

Diols and sugar substitutes in attractive toxic sugar baits targeting Aedes aegypti and Aedes albopictus (Diptera: Culicidae) mosquitoes.

H. Pullmann-Lindsley, A. Bartlett-Miller, J. Pitts

The paper evaluates diols and sugar substitutes for their toxicity to Aedes mosquitoes, finding several compounds significantly reduce survivorship and suggesting their use in attractive toxic sugar baits.

bioRxiv · Feb 9, 2023 · PreprintPharmacology & Toxicology

Anellovirus Structure Reveals a Mechanism for Immune Evasion

K. A. Swanson, S.-H. Liou, S. Delagrave, R. Hajiar, Y. Chang, N. Yozwiak, T. Ong, H. Rodgers, N. Cohen, Y. Zhang, N. Mukund Acharekar, S. Islam, L. Zaheb, C. Arze, H. Swaminathan, J. Pitts

This paper determines the structure of an anellovirus, revealing how its unique surface features enable immune evasion by hiding conserved epitopes and exposing diverse ones as decoys.

bioRxiv · Jul 1, 2022Biochemistry

Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

J. Pitts, J. Li, J. Perry, V. Du Pont, N. Riola, L. Rodriguez, X. Lu, C. Kurhade, X. Xie, G. Camus, S. Manhas, R. Martin, P.-Y. Shi, T. Cihlar, D. P. Porter, , J. P. Bilello

This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.

bioRxiv · Feb 9, 2022Microbiology

Reduced binding and neutralization of infection- and vaccine-induced antibodies to the B.1.351 (South African) SARS-CoV-2 variant

V. V. Edara, C. Norwood, K. Floyd, L. Lai, M. E. Davis-Gardner, W. H. Hudson, G. Mantus, L. E. Nyhoff, M. W. Adelman, R. Fineman, S. Patel, R. Byram, D. N. Gomes, G. Michael, H. Abdullahi, , M. S. Suthar

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

bioRxiv · Feb 20, 2021 · PreprintImmunology

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.

A. J. Pruijssers, A. S. George, A. Schäfer, S. R. Leist, L. E. Gralinski, K. H. Dinnon, B. L. Yount, M. L. Agostini, L. J. Stevens, J. D. Chappell, X. Lu, T. M. Hughes, K. L. Gully, D. R. Martinez, A. J. Brown, , T. P. Sheahan

This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.

bioRxiv · Apr 27, 2020Microbiology