SWI/SNF Alterations Define a Chromatin-Dependent Subtype of Urothelial Carcinoma
Bing Feng, Kaniz Fatema, David Austin Nix, Aaron E. Atkinson, Constance Caparas, Chris Stubben, David Henry Lum, Timothy J. Parnell, Courtney Carroll, G. Daniel Grass, Laura Graham, Eric A. Singer, Kenneth Gerard Nepple, Zarko Manojlovic, ERIC C. KAUFFMAN, , Sumati V. Gupta
This paper identifies a chromatin-altered subtype of urothelial carcinoma defined by SWI/SNF alterations, showing it is sensitive to HDAC inhibition and immunotherapy.
bioRxiv · Aug 6, 2026 · PreprintCancer Biology