Author

A. S. Don

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. J. Hoy· 2 shared D. E. James· 2 shared A. D. Vegas· 1 shared A. Garfield· 1 shared A. M. Scott· 1 shared A. P. Ryan· 1 shared B. C. Bergman· 1 shared C. Y. Mah· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

A. J. Hoy

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Acetyl-CoA carboxylase 1-dependent lipogenesis drives breast cancer progression

K. Tan, T. Owen, H. P. McEwen, P. Simpson, A. J. Hoy, D. E. James, A. S. Don, M. J. Naylor

This study shows ACC1 drives breast cancer progression through lipogenesis, with ACC1 knockout reducing tumor growth and altering lipid profiles in both mouse models and human cells.

bioRxiv · Jul 20, 2023 · PreprintCancer Biology

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

A. D. Vegas, S. Madsen, K. C. Cooke, L. Carroll, J. X. Y. Khor, N. Turner, X. Y. Lim, M. A. Astore, J. Morris, A. S. Don, A. Garfield, S. Zarini, K. A. Zemski Berry, A. P. Ryan, B. C. Bergman, , J. G. Burchfield

The paper links mitochondrial ceramide, CoQ, and the respiratory chain in a pathway driving insulin resistance in skeletal muscle, showing protective effects of reducing ceramide or supplementing CoQ.

bioRxiv · Mar 10, 2023 · PreprintCell Biology

A novel function of sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids.

T. A. Couttas, Y. H. Rustam, H. Song, Y. Qi, J. D. Teo, J. Chen, G. E. Reid, A. S. Don

This study identifies a novel role for sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids, showing that its absence leads to their accumulation in the brain due to slower catabolism.

bioRxiv · Feb 14, 2020Biochemistry

DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Z. D. Nassar, C. Y. Mah, J. Dehairs, I. J. G. Burvenich, S. Irani, M. M. Centenera, R. K. Shrestha, M. Moldovan, A. S. Don, A. M. Scott, L. G. Horvath, D. J. Lynn, L. A. Selth, A. J. Hoy, J. V. Swinnen, L. M. Butler

This study identifies DECR1 as an androgen-repressed gene that promotes prostate cancer cell survival by facilitating PUFA oxidation and preventing ferroptosis.

bioRxiv · Dec 6, 2019Cancer Biology