S. Nie

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Virally induced lipid droplets are a platform for innate immune signalling complexes

This study shows that virally induced lipid droplets host antiviral signaling proteins and undergo dynamic proteome and lipidome changes to support innate immune responses.

Spatiotemporal coordination of Rac1 and Cdc42 at the whole cell level during cell ruffling

This study uses a simulation model to show that membrane velocity during cell ruffling is controlled by GTPase activation kinetics, not concentration, and that time delays between Rac1 and Cdc42 activation can be explained by feedback loops.

Lipid remodeling by hypoxia aggravates migratory potential in pancreatic cancer while maintaining membrane homeostasis

This study shows hypoxia-induced lipid remodeling in pancreatic cancer cells increases migratory potential without altering membrane biophysical properties.

Coordinated Regulation of Cdc42ep1, Actin, and Septin Filaments during Neural Crest Cell Migration

This study investigates how septin filaments regulate neural crest cell migration by interacting with actin stress fibers and requiring Cdc42ep1 for their function.

Remodelled Ribosomes Synthesise a Specific Proteome in Proliferating Plant Tissue during Cold

The paper shows that during cold acclimation in barley root meristems, ribosomal proteins are selectively synthesized and assembled, leading to changes in ribosome composition that may influence translation initiation.

Effects of chitin and chitosan on root growth, biochemical defense response and exudate proteome of Cannabis sativa

This study examines how chitin and chitosan affect Cannabis sativa root growth, defense responses, and exudate proteome, finding that chitosan enhances defense protein production and secretion.

Lipidomic profiling reveals concerted temporal patterns of functionally related lipids in Aedes aegypti females following blood feeding

This study identifies temporal lipidomic changes in Aedes aegypti mosquitoes post-blood meal, highlighting functional lipid patterns linked to reproduction.

Architecture of the cytoplasmic face of the nuclear pore

The paper establishes the near-atomic molecular architecture of the cytoplasmic face of the human nuclear pore complex using interdisciplinary methods.

Architecture of the linker-scaffold in the nuclear pore

The paper establishes the near-atomic molecular architecture and evolutionary conservation of the linker-scaffold in the human nuclear pore complex.

Getting more out of FLAG-Tag co-immunoprecipitation mass spectrometry experiments using FAIMS.

This study shows that using FAIMS in FLAG-Tag co-immunoprecipitation improves protein coverage by reducing tag peptide interference in mass spectrometry.

What are we missing by using hydrophilic enrichment? Improving bacterial glycoproteome coverage using total proteome and FAIMS analysis.

This study shows that FAIMS fractionation can enrich glycopeptides missed by HILIC, increasing glycoproteome coverage in bacteria by at least 30%.

Widespread remodelling of proteome solubility in response to different protein homeostasis stresses

The paper measures proteome solubility changes in Neuro2a cells under various protein homeostasis stresses and finds widespread remodelling with specific patterns of solubility shifts.