Author

R. Seifert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:human· 2 Assay:imaging· 2

Frequent Co-Authors

H. G. Koerschen· 2 shared H. Hamzeh· 2 shared L. Alvarez· 2 shared R. Pascal· 2 shared U. B. Kaupp· 2 shared W. Boenigk· 2 shared A. Gong· 1 shared A. Hamiot· 1 shared

Activity by Year

2021-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiophysics

H. G. Koerschen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Traction Force Microscopy with DNA FluoroCubes

A. Mortazavi, J. Jiang, P. Laric, D. Helmerich, R. Seifert, S. Gavrilovic, M. Sauer, B. Sabass

This paper introduces FluoroCubes as fiducial markers for traction force microscopy, enabling high-resolution force mapping with improved sensitivity and compatibility with TIRF microscopy.

bioRxiv · Apr 12, 2024Biophysics

Deciphering rapid cell signaling and control of cell motility by reverse opto-chemical engineering

H. Hamzeh, A. Gong, M. Balbach, D. Fridman, H. G. Koerschen, R. Pascal, F. Lavryk, A. Rennhack, R. Seifert, A. Hernandez-Clavijo, S. Pifferi, V. Dusend, B. Fleischmann, P. Sasse, A. Menini, , U. B. Kaupp

This paper introduces ROCE to study cell signaling and motility by using light to control and observe cellular responses in various cell types.

bioRxiv · Feb 26, 2024Biophysics

SAVED by a toxin: Structure and function of the CRISPR Lon protease.

C. Rouillon, N. Schneberger, H. Chi, M. F. Peter, M. Geyer, W. Boenigk, R. Seifert, M. F. White, G. Hagelueken

The paper reports the crystal structure of CRISPR-Lon, a protein that activates by binding cA4 and cleaves CRISPR-T to release a nuclease-like fragment.

bioRxiv · Dec 6, 2021Biochemistry

Immune, endothelial and neuronal network map in human lymph node and spleen

S. Currlin, H. Nick, M. Jorgensen, J. Nick, M. Brusko, H. Hakimian, J. Penaloza-Aponte, N. Rodriguez, M. Medina-Serpas, M. Yang, R. Seifert, I. Kusmartseva, T. Brusko, K. Otto, A. Posgai, , M. A. Atkinson

The paper maps immune, endothelial, and neuronal networks in human spleen and lymph node using multiplex imaging, revealing novel cellular localization patterns.

bioRxiv · Oct 20, 2021 · PreprintImmunology

c-di-AMP signaling is required for bile salts resistance and long-term colonization by Clostridioides difficile

M. Oberkampf, A. Hamiot, P. Altamirano-Silva, P. Belles-sancho, Y. D. Tremblay, N. DiBenedetto, R. Seifert, O. SOUTOURINA, L. Bry, B. Dupuy, J. PELTIER

This study identifies c-di-AMP as a key signaling molecule in Clostridioides difficile that regulates osmolyte uptake and bile salt resistance, essential for gut colonization.

bioRxiv · Aug 23, 2021 · PreprintMicrobiology

A GGDEF domain serves as a spatial on-switch for a phosphodiesterase by direct interaction with a polar landmark protein

T. Rick, V. Kreiling, A. Hoing, S. Fiedler, T. Glatter, W. Steinchen, G. Hochberg, H. Bahre, R. Seifert, G. Bange, S. K. Knauer, P. L. Graumann, K. M. Thormann

The paper shows how the GGDEF domain of PdeB acts as a spatial on-switch by interacting with HubP to restrict phosphodiesterase activity to the flagellated cell pole, influencing surface interaction and environmental spreading.

bioRxiv · Aug 12, 2021Microbiology

External fertilization is orchestrated by a pH-regulated soluble adenylyl cyclase controlling sperm motility and chemotaxis

H. G. Koerschen, H. Hamzeh, R. Pascal, L. Alvarez, W. Boenigk, N. Kaur, L. Levin, J. Buck, C. Kambach, M. Michino, A. Jennings, A. Sato, R. Seifert, T. Struenker, C. Steegborn, U. B. Kaupp

This paper identifies a pH-regulated soluble adenylyl cyclase in non-mammalian sperm that controls motility and chemotaxis, revealing evolutionary adaptations to aquatic environments.

bioRxiv · Jun 18, 2021 · PreprintBiophysics