TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts
S. E. White, T. A. Schwartze, A. Mukundan, C. Schoenherr, S. P. Singh, M. van Dinther, K. T. Cunningham, M. P. J. White, T. Campion, J. Pritchard, C. S. Hinck, P. ten Dijke, G. Inman, R. M. Maizels, A. P. Hinck
This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.
bioRxiv · Dec 22, 2023 · PreprintBiochemistry