P. ten Dijke

Balance Between EGF/STAT1 and IFNγ/NRF2 Signaling Controls ECM1 Expression and Determines Hepatic Homeostasis versus Chronic Liver Disease

This study identifies EGF/STAT1 and IFNγ/NRF2 signaling pathways regulating ECM1 expression, showing their role in maintaining liver homeostasis versus promoting chronic liver disease.

TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

The helminth TGF-beta mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-beta receptors to preferentially target myeloid cells

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches

This study creates a spatial proteogenomic atlas of the liver across species, identifying conserved macrophage niches and their regulatory mechanisms.

Dissection of N-, O- and glycosphingolipid glycosylation changes in PaTu-S pancreatic adenocarcinoma cells upon TGF-β challenge

This study examines how TGF-β affects glycosylation patterns in pancreatic cancer cells, identifying N-glycome changes linked to SOX4 expression and SMAD4 deficiency.

Breast cancer dormancy is associated with a 4NG1 state and not senescence

The paper characterizes breast cancer dormancy in cell lines, showing D2.OR cells enter a 4NG1 state rather than senescence, and can be reversed.

TRAF4 inhibits bladder cancer progression by promoting BMP/SMAD signalling pathway

This study identifies TRAF4 as a tumor suppressor in bladder cancer that promotes BMP/SMAD signaling and inhibits metastasis by targeting SMURF1 for degradation.

Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish

This study identifies cercosporamide as a BMP type I receptor kinase inhibitor that rescues developmental defects in zebrafish embryos.

Transforming growth factor-beta signaling via ALK1 and ALK5 regulates distinct functional pathways in vein graft intimal hyperplasia

This study shows TGF{beta} signals through ALK1 and ALK5 in vein graft SMCs, with ALK5 promoting contractility and ALK1 driving migration, suggesting balancing these pathways could prevent graft failure.

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

This paper develops a fluorescent small-molecule probe to monitor UCHL1 activity in live cells and zebrafish embryos, showing specificity for UCHL1 over other DUBs.