R. M. Maizels

TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts

This paper shows TGM6, a helminth protein, mimics TGF-β binding to TβRII to inhibit TGF-β signaling in fibroblasts but not T cells.

Tuft cell-derived acetylcholine is an effector of type 2 immunity and directly targets helminth parasites in the gut lumen

The paper shows tuft cells release acetylcholine to directly target helminth parasites in the gut, enhancing type 2 immunity.

The helminth TGF-beta mimic TGM4 is a modular ligand that binds CD44, CD49d and TGF-beta receptors to preferentially target myeloid cells

This paper identifies TGM4, a helminth TGF-beta mimic, as a modular ligand that selectively targets myeloid cells through specific receptor interactions, differing from TGM1's broader T cell targeting.

IL-33-binding HpARI family homologues with divergent effects in suppressing or enhancing Type 2 immune responses

The paper identifies three HpARI family members in H. polygyrus bakeri, showing they have distinct effects on IL-33-dependent Type 2 immune responses.

A PD-1-ST2 axis controls Th2 effector function in tissue via a metabolic checkpoint

This study shows that PD-1 signaling regulates Th2 cell metabolism and IL-33 receptor expression through fatty acid oxidation, suggesting PD-1 blockade could treat Th2-related diseases.

Exogenous TGFβ1 and its mimic HpTGM attenuate the heart's inflammatory response to ischaemic injury and improve long term cardiac outcomes

This study shows that exogenous TGFβ1 and its mimic HpTGM reduce inflammation and infarct size after myocardial infarction, improving cardiac outcomes.

A helminth mimic of TGF-β, TGM, enhances regenerative cutaneous wound healing and modulates immune cell recruitment and activation

This study shows that TGM, a helminth-derived TGF-β mimic, accelerates wound healing and reprograms macrophage activation through TGF-β receptor interactions.

Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response

This study shows IL-10 promotes Th2 responses and suppresses IFNγ in intestinal helminth infection by regulating Th1 cells.

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

This study shows that the chaperonin CCT8 is essential for T cell maturation, selection, and function by maintaining proteostasis, and its absence impairs immune protection against helminths.