Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
M. Carreno, M. F. Pires, S. R. Woodcock, T. Brzoska, S. Ghosh, S. R. Salvatore, M. Dunn, N. Connors, S. Yuan, A. C. Straub, S. G. Wendell, G. J. Kato, B. A. Freeman, S. Ofori-Acquah, P. Sundd, , D. A. Vitturi
The paper identifies Kyn-CKA as a kynurenine-derived electrophile that reduces inflammation and prevents vaso-occlusion in sickle cell disease.
bioRxiv · Feb 8, 2022Immunology