Author

B. A. Freeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

F. J. Schopfer· 3 shared S. R. Woodcock· 3 shared A. C. Straub· 2 shared A. Alp· 1 shared A. Casey· 1 shared A. Fagunloye· 1 shared A. Klinke· 1 shared A. Koudelka· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPathology

F. J. Schopfer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction

M. Mueller, T. Schubert, C. Welke, T. J. Schulz, T. Patschkowski, T. Maske, L. A. Lengenfelder, L. Landwehrjohann, E. Donhauser, E. T. Vogt, B. Stratmann, J. Hense, S. Luedtke, M. Duefer, E. Tolstik, , A. Klinke

NO2-OA treatment improves diastolic dysfunction in HFpEF mice by enhancing mitochondrial biogenesis and oxidative phosphorylation.

bioRxiv · Feb 20, 2024 · PreprintPathology

Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling

A. Koudelka, G. J. Buchan, V. Cechova, J. P. O`Brien, H. Liu, S. R. Woodcock, S. J. Mullett, C. Zhang, B. A. Freeman, S. L. Gelhaus

This paper shows that LXA4 and its 15-oxo metabolite do not activate FPR2 receptor but instead modulate redox-sensitive pathways through electrophilic interactions.

bioRxiv · Feb 6, 2024 · PreprintBiochemistry

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

L. Hong, d. C. Braden, Y. Zhao, J. J. Skoko, F. Chang, S. R. Woodcock, C. Uvale, A. Casey, K. Wood, S. Salavatore, A. Alp, T. Harkness, A. Fagunloye, M. Razzaghi, A. C. Straub, , C. A. Carola

This paper identifies nitroalkenes that inhibit RAD51-mediated homologous recombination, enhancing DNA damage in triple-negative breast cancer cells and showing potential as anticancer agents.

bioRxiv · Aug 11, 2023Pharmacology & Toxicology

Immunomodulatory actions of a kynurenine-derived endogenous electrophile.

M. Carreno, M. F. Pires, S. R. Woodcock, T. Brzoska, S. Ghosh, S. R. Salvatore, M. Dunn, N. Connors, S. Yuan, A. C. Straub, S. G. Wendell, G. J. Kato, B. A. Freeman, S. Ofori-Acquah, P. Sundd, , D. A. Vitturi

The paper identifies Kyn-CKA as a kynurenine-derived electrophile that reduces inflammation and prevents vaso-occlusion in sickle cell disease.

bioRxiv · Feb 8, 2022Immunology