Author

A. C. Straub

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

F. J. Schopfer· 3 shared A. Dosunmu-Ogunbi· 2 shared B. A. Freeman· 2 shared K. Wood· 2 shared S. R. Woodcock· 2 shared S. Yuan· 2 shared A. Alp· 1 shared A. Alsuraimi· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

F. J. Schopfer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

L. Hong, d. C. Braden, Y. Zhao, J. J. Skoko, F. Chang, S. R. Woodcock, C. Uvale, A. Casey, K. Wood, S. Salavatore, A. Alp, T. Harkness, A. Fagunloye, M. Razzaghi, A. C. Straub, , C. A. Carola

This paper identifies nitroalkenes that inhibit RAD51-mediated homologous recombination, enhancing DNA damage in triple-negative breast cancer cells and showing potential as anticancer agents.

bioRxiv · Aug 11, 2023Pharmacology & Toxicology

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

A. Gorelova, M. Berman, M. Sharifi-Sanjani, A. Pulgarin Rocha, A. Alsuraimi, P. Riva, V. Negi, T. Bertero, D. Goncharov, T. Kudryashova, A. Dosunmu-Ogunbi, A. Rajaratnam, L. Harvey, M. Nouraie, J. Baust, , I. Al Ghouleh

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

bioRxiv · May 31, 2022 · PreprintCell Biology

Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

S. M. Emrich, R. E. Yoast, X. Zhang, A. J. Fike, Y.-H. Wang, K. N. Bricker, A. Tao, P. Xin, V. Walter, M. T. Johnson, T. Pathak, A. C. Straub, S. Feske, Z. Rahman, M. Trebak

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.

bioRxiv · May 6, 2022Immunology

Immunomodulatory actions of a kynurenine-derived endogenous electrophile.

M. Carreno, M. F. Pires, S. R. Woodcock, T. Brzoska, S. Ghosh, S. R. Salvatore, M. Dunn, N. Connors, S. Yuan, A. C. Straub, S. G. Wendell, G. J. Kato, B. A. Freeman, S. Ofori-Acquah, P. Sundd, , D. A. Vitturi

The paper identifies Kyn-CKA as a kynurenine-derived electrophile that reduces inflammation and prevents vaso-occlusion in sickle cell disease.

bioRxiv · Feb 8, 2022Immunology

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

S. Yuan, S. Hahn, M. P. Miller, S. Sanker, M. Calderon, M. Sullivan, A. Dosunmu-Ogunbi, M. Fazzari, Y. Li, M. Reynolds, K. Wood, C. St. Croix, D. Stolz, E. Cifuentes-Pagano, P. Navas, , A. C. Straub

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Redox Biology · Nov 1, 2021Peer-reviewedCell Biology