F. J. Schopfer

Enhanced cardiac mitochondrial biogenesis by nitro-oleic acid remedies diastolic dysfunction in a mouse model of heart failure with preserved ejection fraction

NO2-OA treatment improves diastolic dysfunction in HFpEF mice by enhancing mitochondrial biogenesis and oxidative phosphorylation.

Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.

This paper identifies nitroalkenes that inhibit RAD51-mediated homologous recombination, enhancing DNA damage in triple-negative breast cancer cells and showing potential as anticancer agents.

Western diet unmasks transient low-level vinyl chloride exposure-induced tumorigenesis; potential role of the (epi-)transcriptome

This study shows that low-level vinyl chloride exposure combined with a Western diet increases liver cancer risk in mice through metabolic and epitranscriptomic changes.

Immunomodulatory actions of a kynurenine-derived endogenous electrophile.

The paper identifies Kyn-CKA as a kynurenine-derived electrophile that reduces inflammation and prevents vaso-occlusion in sickle cell disease.

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

This study shows CYB5R3 modulates NOX4 activity via coenzyme Q to reduce endothelial inflammation, with in vivo and in vitro evidence of their interaction and functional dependency.

Exogenous Nitro-Oleic Acid inhibits primary root growth by reducing the mitosis in the meristem in Arabidopsis thaliana

This study shows that exogenous nitro-oleic acid inhibits Arabidopsis primary root growth by reducing mitosis in the meristem, without affecting auxin or cytokinin responses.