Author

G. L. Isom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:E. coli· 4 Research Focus:protein structure prediction· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. C. Ekiert· 4 shared G. Bhabha· 4 shared N. Coudray· 4 shared M. R. MacRae· 3 shared A. Delhaye· 1 shared A. F. Cunningham· 1 shared B. Zhang· 1 shared C. Icke· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

D. C. Ekiert

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Author profile →

5 papers

Recent·Most cited

Role of Ring6 in the function of the E. coli MCE protein LetB

C. Vieni, N. Coudray, G. L. Isom, G. Bhabha, D. C. Ekiert

This study investigates the role of MCE domains in LetB, an E. coli protein, finding that deletion of Ring3 or Ring6 increases resistance to membrane perturbing agents and revealing a model for tunnel gating.

bioRxiv · Sep 30, 2021Biochemistry

YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth.

E. C. A. Goodall, G. L. Isom, J. L. Rooke, C. Icke, K. Pullela, B. Zhang, J. Rae, W. B. Tan, M. Winkle, A. Delhaye, E. Heinz, J.-F. Collet, A. F. Cunningham, M. A. Blaskovich, R. G. Parton, , I. R. Henderson

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

bioRxiv · Apr 16, 2021Microbiology

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

N. Coudray, G. L. Isom, M. R. MacRae, M. N. Saiduddin, G. Bhabha, D. C. Ekiert

The paper reports the cryo-EM structure of the MlaFEDB complex with bound phospholipids, revealing its transport mechanism and substrate binding.

bioRxiv · Jun 2, 2020Biochemistry

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

L. R. Kolich, Y.-T. Chang, N. Coudray, S. I. Giacometti, M. R. MacRae, G. L. Isom, E. M. Teran, G. Bhabha, D. C. Ekiert

The paper reports the X-ray structure of MlaFB from E. coli, revealing how the regulatory subunit MlaB stabilizes the nucleotide binding domain and how the C-terminal tail of MlaF mediates dimerization and complex assembly.

bioRxiv · Apr 27, 2020Microbiology

Structure of LetB reveals a tunnel for lipid transport across the bacterial envelope

G. L. Isom, N. Coudray, M. R. MacRae, C. T. McManus, D. C. Ekiert, G. Bhabha

The paper determines the structure of LetB, showing it forms a hydrophobic tunnel for lipid transport across the bacterial envelope.

bioRxiv · Aug 28, 2019Biochemistry