Y.-T. Chang

Mitochondrial temperature homeostasis resists external metabolic stresses

The paper measures mitochondrial temperature in various cell lines and finds it remains up to 15°C higher than the external environment under metabolic stress.

SLC25A51 impacts drug sensitivity in AML cells by sustaining mitochondrial oxidative flux

This study shows that SLC25A51 sustains mitochondrial oxidative flux in AML, leading to drug sensitivity when inhibited, especially with glutaminase inhibitors.

De novo design of modular peptide binding proteins by superhelical matching

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

This study shows SAMHD1 regulates innate immunity by controlling RNA condensation, preventing immune recognition of self RNA and reducing inflammation.

A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans

This paper identifies a PALS-25 gain-of-function mutant in C. elegans that activates immune responses against both epidermal and intestinal pathogens through cross-tissue signaling.

The predicted bZIP transcription factor ZIP-1 promotes resistance to intracellular infection in Caenorhabditis elegans

This study identifies ZIP-1, a bZIP transcription factor, as a central regulator of the Intracellular Pathogen Response in C. elegans, enhancing resistance to viral and fungal infections.

High Content and High Throughout Phenotypic Assay for the Hourly Resolution of the Malaria Parasite Erythrocytic Cycle

This paper introduces a high-content, high-throughput phenotypic assay for studying the erythrocytic cycle of malaria parasites with hourly resolution.

Structure of MlaFB uncovers novel mechanisms of ABC transporter regulation

The paper reports the X-ray structure of MlaFB from E. coli, revealing how the regulatory subunit MlaB stabilizes the nucleotide binding domain and how the C-terminal tail of MlaF mediates dimerization and complex assembly.

A genetically validated approach to detect inorganic polyphosphates in plants.

The paper develops a method to detect inorganic polyphosphates in plants using a dye and binding domain, finding that higher plants lack large polyP stores.

Mitochondria Are Physiologically Maintained At Close To 50 °C

The paper measures mitochondrial temperature in situ and finds it can exceed 50°C under physiological conditions, influenced by respiratory chain activity and thermogenic enzymes.