Author

L. Thewes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. Berndt· 3 shared A. S. Reichert· 1 shared B. Rotblat· 1 shared C. Ballmeyer· 1 shared C. H. Lillig· 1 shared C. Ortegon Salas· 1 shared C. S. Mueller· 1 shared C. Schulzke· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

C. Berndt

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Author profile →

3 papers

Recent·Most cited

Oncogenic RAS signaling is a tumor cell-intrinsic determinant of ferroptosis suppression via induction of the GCH1/BH4 axis

J. K. Lim, F. Stoelting, D. Roth, C. Ballmeyer, S. Tishina, L. Thewes, S. Kalis, S. Boussettaoui, D. Picard, H.-F. Zhang, O. Lewandowska, T. Reiff, T. Levy, B. Rotblat, M. Remke, , G. Leprivier

This study shows oncogenic RAS signaling suppresses ferroptosis by upregulating GCH1 and BH4, making RAS-driven cancers resistant to ferroptosis-inducing agents.

bioRxiv · Jan 27, 2024 · PreprintCancer Biology

JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis

L. Nguyen, M. Westerhoff, L. Thewes, W. Wruck, A. S. Reichert, C. Berndt, J. Adjaye

This study shows JNK signaling supports self-renewal of urine-derived renal progenitor cells by preventing ferroptosis, suggesting its role in kidney disease modeling.

bioRxiv · Aug 24, 2022 · PreprintCell Biology

FeS-cluster coordination of vertebrate thioredoxin regulates suppression of hypoxia-induced factor 2α through iron regulatory protein 1

C. Berndt, E.-M. Hanschmann, L. M. Jordt, M. Gellert, L. Thewes, C. Ortegon Salas, G. Poschmann, C. S. Mueller, Y. Bodnar, S. Schippers, O. Handorf, R. Nowack, J.-M. Moulis, C. Schulzke, V. Schuenemann, C. H. Lillig

The paper shows FeS-cluster coordination of Trx1 regulates hypoxia-induced factor 2α suppression via IRP1 by linking redox and iron homeostasis.

bioRxiv · Aug 4, 2020 · PreprintBiochemistry