Pharmacological and fasting-induced activation of SIRT1/LXRα signaling alleviates diabetes-induced retinopathy.
S. S. Hammer, C. P. Vieira, D. McFarland, M. Sandler, Y. Levitsky, T. F. Dorweiler, T. Lydic, B. Asare-Bediako, Y. Adu-Agyeiwaah, M. S. Sielski, M. Dupont, A. L. Longhini, S. L. Calzi, D. Chakraborty, G. M. Seigel, , J. V. Busik
This study shows that activating SIRT1 signaling through fasting or pharmacology reduces diabetes-induced retinopathy by improving cholesterol metabolism, reducing inflammation, and preserving neural function.
bioRxiv · Dec 10, 2019 · PreprintCell Biology