Author

T. Lydic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. L. Longhini· 2 shared B. Asare-Bediako· 2 shared C. P. Vieira· 2 shared J. V. Busik· 2 shared M. B. Grant· 2 shared M. Dupont· 2 shared M. S. Sielski· 2 shared S. S. Hammer· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

A. L. Longhini

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Author profile →

4 papers

Recent·Most cited

ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes

A. Kostina, Y. Lewis-Israeli, M. Abdelhamid, M. Gabalski, B. Volmert, H. Lankerd, A. Huang, A. Wasserman, T. Lydic, C. Chan, I. Olomu, A. Aguirre

This study uses human heart organoids to show that pregestational diabetes causes ER stress and lipid imbalance, leading to cardiomyopathy, and identifies potential therapeutic targets.

bioRxiv · Jun 7, 2023 · PreprintBioengineering

Selective LXR agonist, DMHCA, corrects the retina-bone marrow axis in type 2 diabetes

C. P. Vieira, S. D. Fortmann, M. Hossain, A. L. Longhini, S. S. Hammer, B. Asare-Bediako, D. K. Crossman, M. S. Sielski, Y. Adu-Agyeiwaah, M. Dupont, J. L. Floyd, S. Li Calzi, T. Lydic, R. S. Welner, G. J. Blanchard, , M. B. Grant

This study shows that DMHCA, a selective LXR agonist, corrects the retina-bone marrow axis in type 2 diabetes by restoring retinal function, cholesterol homeostasis, and hematopoietic stem cell balance.

bioRxiv · Feb 11, 2020 · PreprintCell Biology

Pharmacological and fasting-induced activation of SIRT1/LXRα signaling alleviates diabetes-induced retinopathy.

S. S. Hammer, C. P. Vieira, D. McFarland, M. Sandler, Y. Levitsky, T. F. Dorweiler, T. Lydic, B. Asare-Bediako, Y. Adu-Agyeiwaah, M. S. Sielski, M. Dupont, A. L. Longhini, S. L. Calzi, D. Chakraborty, G. M. Seigel, , J. V. Busik

This study shows that activating SIRT1 signaling through fasting or pharmacology reduces diabetes-induced retinopathy by improving cholesterol metabolism, reducing inflammation, and preserving neural function.

bioRxiv · Dec 10, 2019 · PreprintCell Biology

Elevated O-GlcNAcylation Enhances Pro-Inflammatory Th17 Function by Altering the Lipid Microenvironment

M. Machacek, Z. Zhang, E. P. Tan, J. Li, T. Li, M. T. Villar, A. Artigues, T. Lydic, C. Slawson, P. Fields

The paper shows that elevated O-GlcNAcylation in CD4+ T cells enhances Th17 function by altering the lipid microenvironment, increasing IL-17A production in obesity.

bioRxiv · Apr 20, 2018Immunology