Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)
G. Pharaoh, V. Kamat, S. Kannan, R. S. Stuppard, J. Whitson, M. Martin-Perez, W.-J. Qian, M. J. MacCoss, J. Villen, P. Rabinovitch, M. D. Campbell, I. R. Sweet, D. J. Marcinek
This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.
bioRxiv · Feb 1, 2023 · PreprintPhysiology