Author

M. D. Campbell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 4 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:metabolism & bioenergetics· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:human· 1

Frequent Co-Authors

D. J. Marcinek· 4 shared P. S. Rabinovitch· 3 shared D. Marcinek· 2 shared I. R. Sweet· 2 shared J. A. Whitson· 2 shared J. Villen· 2 shared M. J. MacCoss· 2 shared M. Martin-Perez· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersPhysiology

D. J. Marcinek

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Age and sex dependent effects of metabolic response to muscle contraction

M. D. Campbell, D. Djukovic, D. Raftery, D. Marcinek

This study investigates age and sex differences in mitochondrial substrate utilization during muscle contraction, finding that aged muscle shows altered fatty acid oxidation and metabolic responses to different exercise protocols.

bioRxiv · May 30, 2023 · PreprintPhysiology

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

G. Pharaoh, V. Kamat, S. Kannan, R. S. Stuppard, J. Whitson, M. Martin-Perez, W.-J. Qian, M. J. MacCoss, J. Villen, P. Rabinovitch, M. D. Campbell, I. R. Sweet, D. J. Marcinek

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice

M. D. Campbell, A. T. Samuelson, Y. A. Chiao, M. T. Sweetwyne, W. C. Ladiges, P. S. Rabinovitch, D. Marcinek

This study shows that intermittent elamipretide injections in aged mice preserve exercise tolerance and skeletal muscle function but not heart or kidney function, unlike continuous treatment.

bioRxiv · Nov 29, 2022Physiology

Evaluation of sex and age effects of fiber damage before permeabilization on mitochondrial respiration

M. D. Campbell, D. J. Marcinek

This study evaluates how age, sex, and biopsy methods affect mitochondrial respiration in mouse muscle fibers and introduces a protocol to reduce variability.

bioRxiv · Nov 29, 2022 · PreprintPhysiology

Elamipretide (SS-31) Treatment Attenuates Age-Associated Post-Translational Modifications of Heart Proteins

J. A. Whitson, M. Martin-Perez, T. Zhang, M. J. Gaffrey, G. E. Merrihew, E. Huang, C. C. White, T. J. Kavanagh, W.-J. Qian, M. D. Campbell, M. J. MacCoss, D. J. Marcinek, J. Villen, P. S. Rabinovitch

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

bioRxiv · Aug 6, 2021Cell Biology

Metabolic function in aging retina and retinal pigment epithelium remains robust despite vision loss

K. A. Tsantilas, W. M. Cleghorn, C. M. Bisbach, J. A. Whitson, D. T. Hass, B. M. Robbings, M. Sadilek, J. D. Linton, A. M. Rountree, A. P. Valencia, M. T. Sweetwyne, M. D. Campbell, H. Zhang, C. S. R. Jankowski, I. R. Sweet, , J. B. Hurley

This study examines metabolic changes in aging mouse retina and eyecup, finding stable glucose and glutamine metabolism despite vision loss.

bioRxiv · Apr 6, 2021Biochemistry