Author

W.-J. Qian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 6 Approach:experimental assay· 6 Assay:proteomics· 6 Research Focus:cell type annotation· 5 Organism:mouse· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

M. J. MacCoss· 3 shared D. J. Marcinek· 2 shared J. M. Fulcher· 2 shared J. Villen· 2 shared J. Whitson· 2 shared M. D. Campbell· 2 shared M. J. Gaffrey· 2 shared M. Martin-Perez· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

M. J. MacCoss

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Author profile →

7 papers

Recent·Most cited

A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis

I. Diaz Ludovico, S. M. Powell, G. Many, L. Bramer, S. Sarkar, K. Stratton, T. Liu, T. Shi, W.-J. Qian, K. E. Burnum-Johnson, J. T. Melchior, E. S. Nakayasu

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

PROTEOMICS · Jun 19, 2024Peer-reviewedBiochemistry

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT)

G. Pharaoh, V. Kamat, S. Kannan, R. S. Stuppard, J. Whitson, M. Martin-Perez, W.-J. Qian, M. J. MacCoss, J. Villen, P. Rabinovitch, M. D. Campbell, I. R. Sweet, D. J. Marcinek

This paper shows that Elamipretide improves ADP sensitivity in aged mitochondria by enhancing ADP uptake through the ANT, leading to improved muscle and heart function.

bioRxiv · Feb 1, 2023 · PreprintPhysiology

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

Y.-C. Chen, A. J. Taylor, J. M. Fulcher, A. C. Swensen, X.-Q. Dai, M. Komba, K. L. C. Wrightson, K. Fok, A. E. Patterson, R. I. Klein-Geltink, P. E. MacDonald, W.-J. Qian, C. B. Verchere

This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.

bioRxiv · Oct 20, 2022 · PreprintPhysiology

Elamipretide (SS-31) Treatment Attenuates Age-Associated Post-Translational Modifications of Heart Proteins

J. A. Whitson, M. Martin-Perez, T. Zhang, M. J. Gaffrey, G. E. Merrihew, E. Huang, C. C. White, T. J. Kavanagh, W.-J. Qian, M. D. Campbell, M. J. MacCoss, D. J. Marcinek, J. Villen, P. S. Rabinovitch

This study investigates how elamipretide affects age-related post-translational modifications in mouse heart proteins, finding that it reverses oxidative changes but not phosphorylation changes.

bioRxiv · Aug 6, 2021Cell Biology

Enhancing top-down proteomics of brain tissue with FAIMS

J. M. Fulcher, A. Makaju, R. J. Moore, M. Zhou, D. C. Bennett, P. L. De Jager, W.-J. Qian, L. Pasa-Tolic, V. A. Petyuk

This study shows that adding FAIMS to top-down proteomics improves proteome coverage in Alzheimer's brain tissue by doubling the number of non-redundant proteoforms identified.

bioRxiv · Jan 18, 2021Biochemistry

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Y. A. Chiao, H. Zhang, M. Sweetwyne, J. Whitson, Y. S. Ting, N. Basisty, L. Pino, E. Quarles, N.-H. Nguyen, M. Campbell, T. Zhang, M. J. Gaffrey, G. Merrihew, L. Wang, Y. Yue, , P. S. Rabinovitch

This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.

bioRxiv · Jan 2, 2020Physiology

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

L. Gerosa, C. Chidley, F. Froehlich, G. Sanchez, S. K. Lim, J. Muhlich, J.-Y. Chen, G. J. Baker, D. Schapiro, T. Shi, L. Yi, C. D. Nicora, A. Claas, D. A. Lauffenburger, W.-J. Qian, , P. K. Sorger

The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.

bioRxiv · Sep 8, 2019Cancer Biology