Author

S. Smits

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Organism:yeast· 2 Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Reiners· 2 shared K. Stuehler· 2 shared A. Harris· 1 shared A. Kedrov· 1 shared A. Kulik· 1 shared A. Marcobal· 1 shared A. Papadopoulos· 1 shared A. Southwick· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

J. Reiners

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The fungal protein Jps1 facilitates unconventional protein secretion through a direct phosphoinositide interaction

S. Dali, M. Schultz, M. Koester, M. Kamel, M. Busch, W. Steinchen, S. Haensch, A. Papadopoulos, J. Reiners, S. Smits, A. Kedrov, F. Altegoer, K. Schipper

This study identifies Jps1 as a key protein facilitating unconventional secretion in Ustilago maydis by interacting with phosphoinositides, revealing its structural and functional roles in Cts1 export.

bioRxiv · Feb 29, 2024 · PreprintBiochemistry

Integrative modeling of guanylate binding protein dimers

W. Schumann, J. Loschwitz, J. Reiners, D. Degrandi, K. Pfeffer, K. Stuehler, G. Poschmann, S. Smits, B. Strodel

The paper models dimer structures of GBP proteins using integrative methods, revealing structural differences that explain functional divergence.

bioRxiv · Dec 20, 2022Biochemistry

A new twist in ABC transporter mediated multidrug resistance - Pdr5 is a drug/proton co-transporter

M. Wagner, D. Blum, S. Raschka, L.-M. Nentwig, C. Gertzen, M. Chen, C. Gatsogiannis, A. Harris, S. Smits, R. Wagner, L. Schmitt

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

bioRxiv · May 26, 2021Biochemistry

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations

K. M. Pruss, A. Marcobal, A. Southwick, D. Dahan, S. Smits, J. Ferreyra, S. Higginbottom, E. Sonnenburg, P. Kashyap, B. Choudhury, L. Bode, J. Sonnenburg

The paper shows that mucin-derived O-glycans can restore microbiota balance and improve host health by promoting beneficial microbes and suppressing pathogens.

bioRxiv · Jun 9, 2020Microbiology

Mechanism of BceAB-type transporter: Resistance by lipid II flipping

J. Zaschke-Kriesche, S. Unsleber, I. Voitsekhovskaia, A. Kulik, L. Behrmann, N. Overbeck, K. Stuehler, E. Stegmann, S. Smits

The paper identifies SaNsrFP as a BceAB-type transporter that confers resistance to antimicrobial peptides by flipping lipid II back into the cytosol, reducing its availability on the cell surface.

bioRxiv · Mar 5, 2020 · PreprintMicrobiology