Author

G. R. Griffith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

H.-J. Chen· 2 shared A. P. Bye· 1 shared A. P. J. Vlaar· 1 shared A. Y. F. Li Yim· 1 shared Amsterdam UMC COVID-19 Biobank· 1 shared C. E. Geyer· 1 shared D. Guerra· 1 shared E. Ferrero· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersImmunology

H.-J. Chen

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

C. E. Geyer, H.-J. Chen, A. P. Bye, X. D. Manz, D. Guerra, T. G. Caniels, T. P. L. Bijl, G. R. Griffith, W. Hoepel, S. W. de Taeye, J. Veth, A. P. J. Vlaar, Amsterdam UMC COVID-19 Biobank, G. Vidarsson, H. J. Bogaard, , J. den Dunnen

The paper identifies SYK and PI3K inhibitors, particularly entospletinib, as effective in counteracting anti-spike IgG-induced hyperinflammation in severe COVID-19.

bioRxiv · Dec 20, 2022Immunology

Defining tissue- and disease-associated macrophages using a transcriptome-based classification model

H.-J. Chen, A. Y. F. Li Yim, G. R. Griffith, W. J. de Jonge, M. M. A. M. Mannens, E. Ferrero, P. Henneman, M. P. J. de Winther

This paper develops a classifier, macIDR, to identify macrophage subtypes from transcriptomic data and applies it to define tissue- and disease-specific macrophage characteristics.

bioRxiv · Jan 29, 2019Immunology