Author

D. Guerra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Organism:virus· 1

Frequent Co-Authors

K. Sliepen· 4 shared M. J. van Gils· 4 shared A. B. Ward· 3 shared G. Kerster· 3 shared I. Bontjer· 3 shared J. L. Torres· 3 shared M. Claireaux· 3 shared M. Poniman· 3 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

K. Sliepen

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Broadening sarbecovirus neutralization with bispecific antibodies combining distinct conserved targets on the receptor binding domain

D. Guerra, L. Radic, M. Brinkkemper, M. Poniman, L. van der Maas, J. L. Torres, A. B. Ward, K. Sliepen, J. Schinkel, R. W. Sanders, M. J. van Gils, T. Beaumont

This study develops bispecific antibodies that target conserved regions on the SARS-CoV-2 spike protein, showing improved neutralization breadth against multiple sarbecovirus strains.

bioRxiv · May 9, 2024Microbiology

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

C. E. Geyer, H.-J. Chen, A. P. Bye, X. D. Manz, D. Guerra, T. G. Caniels, T. P. L. Bijl, G. R. Griffith, W. Hoepel, S. W. de Taeye, J. Veth, A. P. J. Vlaar, Amsterdam UMC COVID-19 Biobank, G. Vidarsson, H. J. Bogaard, , J. den Dunnen

The paper identifies SYK and PI3K inhibitors, particularly entospletinib, as effective in counteracting anti-spike IgG-induced hyperinflammation in severe COVID-19.

bioRxiv · Dec 20, 2022Immunology

Broad SARS-CoV-2 Neutralization by Monoclonal and Bispecific Antibodies Derived from a Gamma-infected Individual

D. Guerra, T. Beaumont, L. Radic, G. Kerster, K. van der Straten, M. Yuan, J. L. Torres, W.-H. Lee, H. Liu, M. Poniman, I. Bontjer, J. A. Burger, M. Claireaux, T. G. Caniels, J. L. Snitselaar, , M. J. van Gils

This study identifies broadly neutralizing monoclonal and bispecific antibodies from a Gamma variant-infected individual that effectively neutralize multiple SARS-CoV-2 variants.

bioRxiv · Oct 14, 2022Immunology

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spike

M. Claireaux, T. G. Caniels, M. de Gast, J. Han, D. Guerra, G. Kerster, B. D. van Schaik, A. Jongejan, A. I. Schriek, M. Grobben, P. J. Brouwer, K. van der Straten, Y. Aldon, J. Capella-Pujol, J. L. Snitselaar, , M. J. van Gils

The paper identifies a novel S2 epitope recognized by a public antibody class in SARS-CoV-2-reactive B cells, which becomes exposed on vaccine-optimized spike proteins.

bioRxiv · Dec 1, 2021Immunology

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

P. Brouwer, T. Caniels, K. van Straten, J. Snitselaar, Y. Aldon, S. Bangaru, J. Torres, N. Okba, M. Claireaux, G. Kerster, A. Bentlage, M. van Haaren, D. Guerra, J. Burger, E. Schermer, , M. van Gils

This study isolates potent neutralizing antibodies from COVID-19 patients that target multiple sites on the SARS-CoV-2 spike protein, offering insights for vaccine design and therapeutic development.

bioRxiv · May 12, 2020Microbiology