Author

H.-J. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Microbiology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 3 Approach:statistical model· 3

Frequent Co-Authors

G. Vidarsson· 4 shared J. den Dunnen· 4 shared C. E. Geyer· 3 shared M. P. J. de Winther· 3 shared S.-L. Tang· 3 shared W. Hoepel· 3 shared A. P. J. Vlaar· 2 shared Amsterdam UMC COVID-19 biobank· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

G. Vidarsson

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Transfer of IgG from Long COVID patients induces symptomology in mice

H.-J. Chen, B. Appelman, H. Willemen, A. Bos, J. Prado, C. E. Geyer, P. Silva Santos Ribeiro, S. Versteeg, M. D. Larsen, E. Schuchner, M. M. K. Bomers, A. H. A. Lavell, Amsterdam UMC COVID-19 biobank, B. Charlton, R. Wust, , J. den Dunnen

This study transfers IgG from Long COVID patients to mice, inducing distinct symptoms based on patient subgroups, supporting a causative role for IgGs in Long COVID.

bioRxiv · May 30, 2024Immunology

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

C. E. Geyer, H.-J. Chen, A. P. Bye, X. D. Manz, D. Guerra, T. G. Caniels, T. P. L. Bijl, G. R. Griffith, W. Hoepel, S. W. de Taeye, J. Veth, A. P. J. Vlaar, Amsterdam UMC COVID-19 Biobank, G. Vidarsson, H. J. Bogaard, , J. den Dunnen

The paper identifies SYK and PI3K inhibitors, particularly entospletinib, as effective in counteracting anti-spike IgG-induced hyperinflammation in severe COVID-19.

bioRxiv · Dec 20, 2022Immunology

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylatedIgG1 in naive but not antigen-experienced vaccinees

J. Van Coillie, T. Pongracz, J. Rahmoeller, H.-J. Chen, C. E. Geyer, L. A. van Vught, J. S. Buhre, T. Sustic, T. L. J. van Osch, M. Steenhuis, W. Hoepel, W. Wang, A. Lixenfeld, J. Nouta, S. Keijzer, , Fatebenefratelli-Sacco Infectious Diseases Physic

The paper examines afucosylated IgG1 responses after BNT162b2 vaccination, finding transient responses in naive individuals that correlate with second-dose antibody levels.

bioRxiv · Feb 14, 2022Immunology

Microbiome restructuring: dominant coral bacterium Endozoicomonas species display differential adaptive capabilities to environmental changes

K. Tandon, Y.-J. Chiou, S.-P. Yu, H. J. Hsieh, C.-Y. Lu, M.-T. Hsu, P.-W. Chiang, H.-J. Chen, N. Wada, S.-L. Tang

This study examines how dominant coral bacteria, Endozoicomonas species, adapt to environmental changes through a reciprocal transplant experiment and genomic analysis.

bioRxiv · Oct 31, 2021 · PreprintMicrobiology

A genomic view of coral-associated Prosthecochloris and a companion sulfate-reducing bacterium

Y.-H. Chen, S.-H. Yang, K. Tandon, C.-Y. Lu, H.-J. Chen, C.-J. Shih, S.-L. Tang

This study identifies and characterizes novel genomes of coral-associated Prosthecochloris and a sulfate-reducing bacterium, revealing their genomic and metabolic traits and a potential syntrophic relationship in coral endolithic communities.

Microbial Genomics · May 5, 2021Peer-reviewedMicrobiology

Prevalence, complete genome and metabolic potentials of a phylogenetically novel cyanobacterial symbiont in the coral-killing sponge, Terpios hoshinota

Y.-H. Chen, H.-J. Chen, C.-Y. Yang, J.-H. Shiu, D. Z. Hoh, P.-W. Chiang, W. S. Chow, C. A. Chen, T.-H. Shih, S.-H. Lin, C.-M. Yang, J. D. Reimer, E. Hirose, B. H. Iskandar, H. Huang, , S.-L. Tang

The paper identifies a novel cyanobacterial symbiont in the coral-killing sponge Terpios hoshinota, characterizes its genome and metabolic potential, and proposes a new genus and species.

bioRxiv · Feb 4, 2021Ecology

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

F. Guirakhoo, L. Kuo, J. Peng, J. H. Huang, B. Kuo, F. Lin, Y.-J. Liu, Z. Liu, G. Wu, S. Ding, K.-L. Hou, J. Cheng, V. Yang, H. Jiang, J. Wang, , C. Y. Wang

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

bioRxiv · Nov 30, 2020 · PreprintImmunology

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses

W. Hoepel, H.-J. Chen, S. Allahverdiyeva, X. Manz, J. Aman, P. Bonta, P. Brouwer, S. de Taeye, T. Caniels, K. van der Straten, K. Golebski, G. Griffith, R. Jonkers, M. Larsen, F. Linty, , J. den Dunnen

Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients induces hyper-inflammatory responses in macrophages, leading to endothelial barrier breakdown and microvascular thrombosis.

bioRxiv · Jul 13, 2020Immunology

Defining tissue- and disease-associated macrophages using a transcriptome-based classification model

H.-J. Chen, A. Y. F. Li Yim, G. R. Griffith, W. J. de Jonge, M. M. A. M. Mannens, E. Ferrero, P. Henneman, M. P. J. de Winther

This paper develops a classifier, macIDR, to identify macrophage subtypes from transcriptomic data and applies it to define tissue- and disease-specific macrophage characteristics.

bioRxiv · Jan 29, 2019Immunology