Author

C. Pietzsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Bukreyev· 4 shared A. Y. Ting· 2 shared E. O. Saphire· 2 shared G. Crynen· 2 shared G. Tsaprailis· 2 shared J. C. de la Torre· 2 shared J. Fang· 2 shared K. F. Cho· 2 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

A. Bukreyev

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.

J. Fang, C. Pietzsch, H. Witwit, G. Tsaprailis, G. Crynen, K. F. Cho, A. Y. Ting, A. Bukreyev, E. O. Saphire, J. C. de la Torre

The paper identifies eRF3a/GSPT1 as a druggable host target for antiviral therapy against Lassa virus by analyzing its interactome using proximity proteomics.

Proceedings of the National Academy of Sciences · Jul 18, 2022Peer-reviewedMicrobiology

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication

J. Fang, C. Pietzsch, G. Tsaprailis, G. Crynen, K. F. Cho, A. Y. Ting, A. Bukreyev, J. C. de la Torre, E. O. Saphire

The paper identifies functional interactors of the Ebola virus polymerase using proximity proteomics and validates their role in promoting viral replication.

bioRxiv · Jul 20, 2021Microbiology

mRNA-1273 efficacy in a severe COVID-19 model: attenuated activation of pulmonary immune cells after challenge

M. Meyer, Y. Wang, D. Edwards, G. R. Smith, A. B. Rubenstein, P. Ramanathan, C. E. Mire, C. Pietzsch, X. Chen, Y. Ge, W. S. Cheng, C. Henry, A. Woods, L. Ma, G. B. E. Stewart-Jones, , A. Bukreyev

This study evaluates mRNA-1273 vaccine efficacy in hamsters, showing reduced pulmonary immune activation and improved disease outcomes after prime-boost vaccination.

bioRxiv · Jan 25, 2021 · PreprintImmunology

Topoisomerase III-beta is required for efficient replication of positive-sense RNA viruses

K. R. Prasanth, M. Hirano, W. S. Fagg, E. McAnarney, S. Chan, X. Xie, A. Hage, C. Pietzsch, A. Bukreyev, R. Rajsbaum, P.-Y. Shi, M. Bedford, S. Bradrick, V. D. Menachery, M. A. Garcia-Blanco

The paper identifies TOP3B as essential for replication of positive-sense RNA viruses, including SARS-CoV-2, suggesting it as a potential antiviral target.

bioRxiv · Mar 24, 2020Microbiology