V. Nair

Comparative Analysis of Multiple Consensus Genomes of the Same Strain of Marek's Disease Virus Reveals Intrastrain Variation

This study compares multiple consensus genomes of the same Marek's Disease Virus strain, revealing intrastrain variation and highlighting the need for multiple genomes to improve interstrain comparisons.

Glomerular Elastic Modulus and Gene Expression PatternsDefine Two Phases of Alport Nephropathy

This study identifies early glomerular changes and gene expression patterns in Alport syndrome, showing ER stress and four genes as key drivers of disease before proteinuria, and highlights potential therapeutic targets.

Genetic exchange in Leishmania is facilitated by IgM natural antibodies

This study shows IgM antibodies facilitate Leishmania genetic hybridization in vitro and in vivo, leading to full genome hybrids and increased genetic exchange.

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

Loss of GdpP function in Staphylococcus aureus leads to β-lactam tolerance and enhanced evolution of β-lactam resistance

This study shows that loss of GdpP function in Staphylococcus aureus increases β-lactam tolerance and facilitates the evolution of β-lactam resistance.

Single nucleus pituitary transcriptomic and epigenetic landscape reveals human stem cell heterogeneity with diverse regulatory mechanisms

The paper characterizes human pituitary stem cells using single nucleus RNA-seq and ATAC-seq, revealing distinct cell types, regulatory mechanisms, and age-related differences.

Nanowires unravel a time-correlated stochastic vectorial process in cells

This study investigates how cells process vectorial cargoes like silicon nanowires, revealing that one-dimensional time-correlated noise drives their realignment and transport through cytoskeletal dynamics.

Loss of genome maintenance accelerates podocyte damage

This study shows that loss of DNA repair gene Ercc1 in podocytes leads to DNA damage, proteinuria, and kidney disease, linked to mTORC1 activation and aging.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

Long-range coupled motions underlie ligand recognition by a chemokine receptor

This study investigates how Site-I interactions in CXCR1 contribute to ligand recognition by CXCL8 through structural plasticity, using NMR and MD simulations.

Quantitative definition of neurobehavior, vision, hearing and brain volumes in macaques congenitally exposed to Zika virus

The paper assesses the feasibility of using a macaque model to study neurodevelopmental deficits from congenital Zika virus exposure and estimates required sample sizes for future studies.

Menthol in Electronic Cigarettes: A Contributor to Respiratory Disease?

This study investigates how menthol in e-cigarettes affects human bronchial epithelium using three in vitro models, finding adverse effects including oxidative stress and inflammation.

Silicon Nanowires for Intracellular Optical Interrogation with Sub-Cellular Resolution

This paper demonstrates the use of silicon nanowires for sub-cellular optical stimulation in cells, showing their viability, calcium flux induction, and electrical coupling capabilities.

Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis

This study identifies scavenger receptor B1 as the receptor for Mycobacterium tuberculosis on airway microfold cells, showing its role in bacterial transcytosis.

Clinically-relevant cell type cross-talk identified from a human lung tumor microenvironment interactome

The paper identifies clinically relevant cell type interactions in the lung tumor microenvironment using RNA-seq data from sorted cell populations.

TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation.

This study shows TRIM5α restricts flavivirus replication by targeting the viral protease for proteasomal degradation, with implications for human susceptibility to emerging flaviviruses.

Neuraminidase Inhibition Contributes to Influenza A Virus Neutralization by Anti-Hemagglutinin Stem Antibodies

This study shows anti-HA stem antibodies neutralize influenza A virus by inhibiting neuraminidase activity, with implications for therapeutic synergy with NA inhibitors.

Differential gene expression in chicken primary B cells infected ex vivo with attenuated and very virulent strains of infectious bursal disease virus (IBDV)

This study compares gene expression in chicken B cells infected with attenuated and very virulent IBDV strains to identify differences in immune response and virulence factors.