Author

G. Roma

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Schuierer· 3 shared A.-M. Zeeman· 2 shared C. H. M. Kocken· 2 shared E. L. Flannery· 2 shared F. Nigsch· 2 shared J. Tchorz· 2 shared M. Beibel· 2 shared S. A. Mikolajczak· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

S. Schuierer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transcriptional profiling of hepatocytes infected with the replicative form of the malaria parasite Plasmodium cynomolgi

G. Mitchell, G. Roma, A. Voorberg-van der Wel, M. Beibel, A.-M. Zeeman, S. Schuierer, L. Torres, E. L. Flannery, C. H. M. Kocken, S. A. Mikolajczak, T. T. Diagana

This study profiles host gene expression in rhesus macaque hepatocytes infected with Plasmodium cynomolgi, identifying modulated host pathways during malaria infection.

bioRxiv · Jul 18, 2022Microbiology

Loss of hepatic Lgr4 and Lgr5 promotes nonalcoholic fatty liver disease

E. Saponara, C. Penno, M. L. Matadamas Guzman, V. Brun, B. Fischer, M. Brousseau, Z.-Y. Wang, P. ODonnell, J. Turner, A. Graff Meyer, L. Bollepalli, G. dArio, G. Roma, W. Carbone, V. Orsini, , H. Ruffner

This study shows that deleting Lgr4/5 in mouse livers disrupts Wnt/β-catenin signaling, leading to fatty liver disease and fibrosis.

bioRxiv · Nov 22, 2021Physiology

Persistence of Plasmodium cynomolgi hypnozoites in cynomolgus monkey iPS-derived hepatocytes

M. Pellisson, A.-M. Zeeman, T. Doll, L. Kirchhofer-Allan, S. Schuierer, G. Roma, E. L. Flannery, S. A. Mikolajczak, C. H. M. Kocken, P. Maeser, M. Rottmann, M. Mueller

This study develops an in vitro model using cynomolgus monkey iPS-derived hepatocytes to study Plasmodium cynomolgi hypnozoite formation and liver stage dormancy, aiding drug discovery.

bioRxiv · Nov 16, 2021 · PreprintCell Biology

Genome-wide screening in human kidney organoids identifies novel aspects of nephrogenesis

R. Ungricht, L. Guibbal, M.-C. Lasbennes, V. Orsini, M. Beibel, A. Waldt, R. Cuttat, W. Carbone, A. Basler, G. Roma, F. Nigsch, J. Tchorz, D. Hoepfner, P. S. Hoppe

This study uses genome-wide CRISPR screening in human kidney organoids to identify novel regulatory mechanisms in nephrogenesis, including a new role for Jagged1 in controlling epithelial proliferation.

bioRxiv · May 26, 2021Cell Biology

A simple and efficient CRISPR technique for protein tagging

F. Zeng, V. Beck, S. Schuierer, I. Garnier, C. Manneville, C. Agarinis, L. Morelli, L. Quinn, J. Knehr, G. Roma, F. Bassilana, M. S. Nash

The paper introduces HiTag, a CRISPR-based method for protein tagging that works in up to 66% of transfected cells with one electroporation.

bioRxiv · Apr 5, 2019Cell Biology