Author

G. S. Yochum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 2 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

M. T. Johnson· 2 shared M. Trebak· 2 shared N. Hempel· 2 shared P. Xin· 2 shared T. Pathak· 2 shared V. Walter· 2 shared A. E. Abdelnaby· 1 shared A. S. Ganapathy· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

M. T. Johnson

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 2, 2023

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

T. Pathak, J. C. Benson, M. T. Johnson…·M. Trebak

This study shows that loss of STIM2 in colorectal cancer promotes tumor growth and metastasis through metabolic reprogramming and activation of the PERK-ATF4 ER stress pathway.

DOI 10.1101/2023.10.02.560521

humanproteomics

𝕏 PostBluesky

Cell BiologybioRxivPreprintApr 11, 2022

Autophagy Increases Occludin Levels to Enhance Intestinal Paracellular Tight Junction Barrier.

K. Saha, A. S. Ganapathy, A. Wang…·P. Nighot

This study shows autophagy increases occludin levels, enhancing intestinal tight junction barrier function through ERK1/2 MAPK signaling.

DOI 10.1101/2022.04.11.487876

mouseproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMay 7, 2020

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter…·M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

DOI 10.1101/2020.05.07.083071

humanproteomics

𝕏 PostBluesky