Author

V. Walter

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 3 Assay:proteomics· 3

Frequent Co-Authors

M. Trebak· 4 shared D. J. DeGraff· 3 shared J. I. Warrick· 3 shared M. T. Johnson· 3 shared N. Hempel· 3 shared P. Xin· 3 shared T. Pathak· 3 shared A. E. Abdelnaby· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

M. Trebak

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway

T. Pathak, J. C. Benson, M. T. Johnson, P. Xin, A. E. Abdelnaby, V. Walter, W. A. Kultun, G. S. Yochum, N. Hempel, M. Trebak

This study shows that loss of STIM2 in colorectal cancer promotes tumor growth and metastasis through metabolic reprogramming and activation of the PERK-ATF4 ER stress pathway.

bioRxiv · Oct 2, 2023 · PreprintCancer Biology

Alternative splice variants of the mitochondrial fission protein DNM1L/Drp1 regulate mitochondrial dynamics and cell fate in ovarian cancer.

Z. Javed, D. H. Shin, W. Pan, S. R. White, Y. S. Kim, A. T. Elhaw, S. Kamlapurkar, Y.-Y. Cheng, J. C. Benson, A. E. Abdelnaby, R. Phaeton, H.-G. Wang, S. Yang, M. L. G. Sullivan, C. St. Croix, , N. Hempel

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

bioRxiv · Sep 20, 2023Cancer Biology

Urothelium-specific expression of mutationally activated Pik3ca initiates early lesions of non-invasive bladder cancer

L. Shuman, J. Pham, T. Wildermuth, X.-R. Wu, V. Walter, J. I. Warrick, D. J. DeGraff

This study creates a mouse model to study PIK3CA mutations in bladder cancer, showing early tumorigenic changes but no progression to invasion without additional genetic factors.

bioRxiv · May 22, 2023 · PreprintCancer Biology

Orai3 and Orai1 are essential for CRAC channel function and metabolic reprogramming in B cells

S. M. Emrich, R. E. Yoast, X. Zhang, A. J. Fike, Y.-H. Wang, K. N. Bricker, A. Tao, P. Xin, V. Walter, M. T. Johnson, T. Pathak, A. C. Straub, S. Feske, Z. Rahman, M. Trebak

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.

bioRxiv · May 6, 2022Immunology

Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including CD274/PD-L1

W. Hu, H. Yamashita, J. Craig, V. Walter, J. I. Warrick, H. Al-Ahmadie, D. J. DeGraff

This study shows that FOXA1 loss in bladder cancer causes widespread epigenetic changes and activates interferon-response genes like PD-L1.

bioRxiv · Sep 11, 2020 · PreprintCancer Biology

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

bioRxiv · May 7, 2020 · PreprintCancer Biology

Repression of Transcription Factor AP-2 Alpha by Peroxisome Proliferator Activated Receptor Gamma Reveals a Novel Transcriptional Circuit in basal-squamous Bladder Cancer

H. Yamashita, Y. Imamura Kawasawa, L. Shuman, Z. Zheng, T. Tran, V. Walter, J. I. Warrick, H. Al-Ahmadie, M. Kaag, P. K. Wong, J. D. Raman, D. J. DeGraff

This study identifies PPARγ repression of TFAP2A and TFAP2C as drivers of the aggressive basal-squamous bladder cancer subtype through RNA-seq and functional analysis.

bioRxiv · Sep 7, 2018 · PreprintCancer Biology