Author

M. Gueguinou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:metabolism & bioenergetics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1

Frequent Co-Authors

C. Vandier· 4 shared A. Robert· 3 shared D. Crottes· 3 shared G. Fromont-Hankard· 2 shared J. Bourgeais· 2 shared J.-F. Dumas· 2 shared M. Trebak· 2 shared O. Herault· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

C. Vandier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Investigation of the heterogeneity of cancer cells using single cell calcium profiling.

A. Bura, C. Caussette, M. Gueguinou, D. Bellanger, A. Robert, M. Cancel, M. Lacouette-Rata, G. Fromont-Hankard, C. Vandier, K. Maheo, T. Brouard, D. Crottes

This study uses single cell calcium profiling combined with machine learning to analyze Ca2+ signature heterogeneity in cancer cells and their remodeling during resistance and cell interactions.

bioRxiv · Jan 14, 2024Cancer Biology

Encoding of the colorectal cancer metabolic program through MICU2

A. Robert, D. Crottes, J. Bourgeais, N. Gueguen, A. Chevrollier, J.-F. Dumas, S. Servais, I. Domingo, S. Chadet, J. Sobilo, O. Herault, T. Lecomte, C. Vandier, W. Raoul, M. Gueguinou

This study investigates the role of MICU2 in colorectal cancer metabolism, showing its importance in mitochondrial function, metabolic flexibility, and tumor progression.

bioRxiv · Oct 31, 2023 · PreprintCancer Biology

Chimeric protein EWS-FLI1 drives cell proliferation in Ewing Sarcoma via overexpression of KCNN1.

M. Dupuy, M. Gueguinou, A. Postec, R. Brion, R. Tesfaye, M. Mullard, L. Regnier, J. Amiaud, M. Potier-Cartereau, A. Chantome, B. Brounais-Le Royer, M. Baud'huin, S. Georges, F. Lamoureux, B. Ory, , F. Verrecchia

This study identifies KCNN1 as a target of EWS-FLI1 and EWS-ERG fusion proteins in Ewing Sarcoma, showing its role in cell proliferation and potential as a therapeutic target.

bioRxiv · Apr 24, 2023 · PreprintCancer Biology

Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer

M. Gueguinou, S. Ibrahim, J. Bourgeais, A. Robert, T. Pathak, X. Zhang, D. Crottes, J. Dupuy, D. Ternant, V. Monbet, R. Guibon, H. Flores-Romero, A. Lefevre, S. Lerondel, A. Le Pape, , T. Lecomte

This study identifies NCLX as a therapeutic target in MSI-driven CRC, showing that curcumin and NCLX inhibitors induce anti-tumoral effects through mitochondrial calcium overload and apoptosis.

bioRxiv · Jan 18, 2022Cancer Biology

Colorectal adenocarcinomas downregulate the mitochondrial Na+/Ca2+ exchanger NCLX to drive metastatic spread

T. Pathak, M. Gueguinou, V. Walter, C. Delierneux, M. T. Johnson, X. Zhang, P. Xin, R. E. Yoast, S. M. Emrich, G. S. Yochum, I. Sekler, W. A. Koltun, D. L. Gill, N. Hempel, M. Trebak

This study shows that reduced NCLX expression in colorectal tumors leads to mtCa2+ overload, promoting metastasis and chemoresistance through mtROS/HIF1 signaling.

bioRxiv · May 7, 2020 · PreprintCancer Biology