Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.
J. Fang, C. Pietzsch, H. Witwit, G. Tsaprailis, G. Crynen, K. F. Cho, A. Y. Ting, A. Bukreyev, E. O. Saphire, J. C. de la Torre
The paper identifies eRF3a/GSPT1 as a druggable host target for antiviral therapy against Lassa virus by analyzing its interactome using proximity proteomics.
Proceedings of the National Academy of Sciences · Jul 18, 2022Peer-reviewedMicrobiology