Author

G. Crynen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Bukreyev· 2 shared A. Y. Ting· 2 shared C. C. Bailey· 2 shared C. Pietzsch· 2 shared E. O. Saphire· 2 shared G. Tsaprailis· 2 shared J. C. de la Torre· 2 shared J. Fang· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

A. Bukreyev

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

A. Pan, C. C. Bailey, T. Ou, J. Xu, X. Liu, B. Hu, G. Crynen, N. Skamangas, N. Bronkema, M. Tran, H. Mu, X. Zhang, Y. Yin, M. D. Alpert, W. He, M. Farzan

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

bioRxiv · Feb 3, 2024Bioengineering

In vivo affinity maturation of murine B cells reprogrammed to express human antibodies

Y. Yin, Y. Guo, Y. Jiang, B. Quinlan, H. Peng, G. Crynen, W. He, L. Zhang, T. Ou, C. C. Bailey, M. Farzan

This study demonstrates that CRISPR-edited murine B cells expressing human antibodies can undergo affinity maturation, generating potent neutralizing antibodies against HIV-1 and SARS-CoV-2.

bioRxiv · Oct 20, 2023 · PreprintBioengineering

Proximity interactome analysis of Lassa polymerase reveals eRF3a/GSPT1 as a druggable target for host directed antivirals.

J. Fang, C. Pietzsch, H. Witwit, G. Tsaprailis, G. Crynen, K. F. Cho, A. Y. Ting, A. Bukreyev, E. O. Saphire, J. C. de la Torre

The paper identifies eRF3a/GSPT1 as a druggable host target for antiviral therapy against Lassa virus by analyzing its interactome using proximity proteomics.

Proceedings of the National Academy of Sciences · Jul 18, 2022Peer-reviewedMicrobiology

Functional interactomes of the Ebola virus polymerase identified by proximity proteomics in the context of viral replication

J. Fang, C. Pietzsch, G. Tsaprailis, G. Crynen, K. F. Cho, A. Y. Ting, A. Bukreyev, J. C. de la Torre, E. O. Saphire

The paper identifies functional interactors of the Ebola virus polymerase using proximity proteomics and validates their role in promoting viral replication.

bioRxiv · Jul 20, 2021Microbiology

Rhes, a Striatal Enriched Protein, Regulates Post-Translational Small-Ubiquitin-like-Modifier (SUMO) Modification of Nuclear Proteins and Alters Gene Expression

S. Subramaniam, O. Rivera, M. Sharma, N. Shahani, G. Crynen, P. Karunadharma, F. McManus, P. Thibault

This study identifies Rhes as a regulator of SUMOylation of nuclear proteins and shows its role in modulating striatal gene expression through SUMO-dependent mechanisms.

bioRxiv · Jun 18, 2020Biochemistry