Author

C. M. Vezina

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 4 Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:flow cytometry· 2

Frequent Co-Authors

H. M. Ruetten· 4 shared W. A. Ricke· 4 shared D. E. Bjorling· 3 shared K. A. Wegner· 3 shared P. Popovics· 3 shared A. Jain· 2 shared A. Malewska· 2 shared C. G. Roehrborn· 2 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersPhysiology

H. M. Ruetten

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Author profile →

8 papers

Recent·Most cited

Steroid hormone imbalance drives macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate

P. Popovics, K. O. Skalitzky, E. Schroeder, A. Jain, S. V. Silver, F. Van Fritz, K. S. Uchtmann, C. M. Vezina, W. A. Ricke

This study shows that steroid hormone imbalance in mice increases macrophage infiltration and Spp1/osteopontin+ foam cell differentiation in the prostate, with OPN knockout reducing these effects.

bioRxiv · Dec 13, 2022Pathology

OSTEOPONTIN DEFICIENCY LEADS TO THE RESOLUTION OF PROSTATIC FIBROSIS AND INFLAMMATION

P. Popovics, A. Jain, K. O. Skalitzky, E. Schroeder, H. M. Ruetten, M. Cadena, K. S. Uchtmann, C. M. Vezina, W. A. Ricke

This study shows that OPN deficiency reduces inflammation and fibrosis in the prostate after E. coli infection in mice.

bioRxiv · Jul 19, 2021 · PreprintPathology

A Uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate

H. M. RUETTEN, J. Sandhu, B. Mueller, P. Wang, H. L. Zhang, K. A. Wegner, M. Cadena, S. Sandhu, L. Abler, J. Zhu, C. A. O'Driscoll, B. Chelgren, Z. Wang, T. Shen, J. Barasch, , C. M. Vezina

This paper develops a mouse model of prostatic inflammation and collagen accumulation using E. coli UTI89 instillations to study aberrant collagen production in the prostate.

bioRxiv · Aug 10, 2020Physiology

An immunohistochemical prostate cell identification key indicates that aging shifts procollagen 1A1 production from myofibroblasts to fibroblasts in dogs prone to prostate-related urinary dysfunction

H. Ruetten, C. Cole, M. Wehber, K. A. Wegner, N. M. Girardi, N. T. Peterson, B. R. Scharpf, M. F. Romero, M. W. Wood, S. A. Colopy, D. E. Bjorling, C. M. Vezina

This paper identifies an aging-related shift in procollagen 1A1 production from myofibroblasts to fibroblasts in the prostate of aging dogs.

PLOS ONE · Jul 29, 2020Peer-reviewedPathology

Urethral luminal epithelia are castration-insensitive progenitors of the proximal prostate

D. B. Joseph, G. H. Henry, A. Malewska, N. Iqbal, H. M. Ruetten, A. E. Turco, L. L. Abler, S. K. Sandhu, M. T. Cadena, V. S. Malladi, J. C. Reese, R. J. Mauck, J. C. Gahan, R. C. Hutchinson, C. G. Roehrborn, , D. W. Strand

The paper identifies urethral luminal epithelia as castration-insensitive progenitors of the proximal prostate using scRNA-seq and flow cytometry in mice and humans.

bioRxiv · Feb 19, 2020Cell Biology

Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia

P. Popovics, W. N. Awadallah, S. Kohrt, T. C. Case, N. L. Miller, E. Ricke, W. Huang, M. Ramirez-Solano, Q. Liu, C. M. Vezina, R. J. Matusik, W. A. Ricke, M. M. Grabowska

This study shows that osteopontin (OPN) is more abundant in symptomatic benign prostatic hyperplasia (S-BPH) compared to incidental BPH, and OPN secretion is stimulated by pro-inflammatory cytokines, driving pro-inflammatory gene expression in stromal cells.

bioRxiv · Dec 23, 2019Pathology

Factors Driving Unique Urination Phenotypes of Male and Female 9-week-old C57BL/6J Mice

H. M. RUETTEN, K. A. Wegner, H. L. Zhang, P. Wang, J. K. Sandhu, S. K. Sandhu, B. R. Mueller, Z. Wang, J. Macoska, R. E. Peterson, D. E. Bjorling, W. A. Ricke, P. C. Marker, C. M. Vezina

This study evaluates how prostate mass and testosterone affect voiding function in male and female mice, finding that testosterone, not prostate size, primarily drives sex differences in urinary function.

bioRxiv · May 27, 2019Physiology

A cellular anatomy of the normal adult human prostate and prostatic urethra

G. H. Henry, A. Malewska, D. B. Joseph, V. S. Malladi, J. Lee, J. Torrealba, R. J. Mauck, J. C. Gahan, G. V. Raj, C. G. Roehrborn, G. C. Hon, M. P. Macconmara, J. C. Reese, R. C. Hutchinson, C. M. Vezina, D. W. Strand

The paper creates a cellular atlas of the normal adult human prostate and prostatic urethra using single-cell RNA sequencing and flow cytometry, identifying two new epithelial cell types.

bioRxiv · Oct 15, 2018Cell Biology