Author

G. V. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

P. T. Spellman· 3 shared A. Adey· 2 shared A. Chitsazan· 2 shared C. Boniface· 2 shared E. Demir· 2 shared G. Thibault· 2 shared J. Eng· 2 shared L. M. Heiser· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

P. T. Spellman

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5 papers

Recent·Most cited

Androgen receptor activity inversely correlates with immune cell infiltration and immunotherapy response across multiple cancer lineages

Y.-M. Hu, F. Zhao, J. Graff, C. Chen, X. Zhao, G. V. Thomas, H. Wu, A. Kardosh, G. Mills, J. Alumkal, A. E. Moran, Z. Xia

The paper examines the relationship between androgen receptor activity and immune cell infiltration, showing that lower AR activity correlates with increased immune activity and better immunotherapy response across multiple cancers.

bioRxiv · May 8, 2024 · PreprintCancer Biology

Multiplex imaging of localized prostate tumors reveals changes in mast cell type composition and spatial organization of AR-positive cells in the tumor microenvironment

C. Ak, Z. Sayar, G. Thibault, E. Burlingame, J. Eng, A. Chitsazan, A. Adey, C. Boniface, P. T. Spellman, G. V. Thomas, R. Kopp, E. Demir, Y. H. Chang, V. Stavrinides, S. E. Eksi

bioRxiv · Aug 18, 2023 · PreprintCancer Biology

Single-cell analysis of localized low- and high-grade prostate cancers

S. E. Eksi, A. Chitsazan, Z. Sayar, A. Fields, R. Kopp, G. V. Thomas, P. T. Spellman, A. Adey

This study uses single-cell chromatin accessibility analysis to identify distinct gene regulatory programs in low- and high-grade prostate cancers, revealing shared transcription factor binding sites and novel neuronal adhesion molecules.

bioRxiv · Apr 16, 2021 · PreprintCancer Biology

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast Cancer

B. E. Johnson, A. L. Creason, J. M. Stommel, J. M. Keck, S. Parmar, C. B. Betts, A. Blucher, C. Boniface, E. Bucher, E. A. Burlingame, T. Camp, K. Chin, J. Eng, J. Estabrook, H. S. Feiler, , J. W. Gray

This paper presents an OMS Atlas from serial biopsies of a metastatic breast cancer patient, linking clinical data to multi-omic and spatial profiles to study therapy-associated heterogeneity and resistance mechanisms.

bioRxiv · Dec 3, 2020Cancer Biology

Identification of clinical combination therapies to induce durable responses in kidney cancers

H.-w. Lue, D. S. Derrick, S. Rao, A. VanGaest, L. Cheng, J. Podolak, S. Lawson, C. Xue, D. Garg, R. White, C. W. Ryan, J. M. Drake, A. Ritz, L. M. Heiser, G. V. Thomas

This study identifies a synergistic combination of cabozantinib and dasatinib that reduces viability and induces tumor regression in NCCRCC, with mechanisms involving MAPK-ERK pathway suppression.

bioRxiv · Jul 25, 2020 · PreprintCancer Biology