G. van den Bogaart

This study shows that LPS rapidly primes trafficking machinery in dendritic cells to enhance polarized IL-6 secretion through phosphorylation of VAMP3.

This study identifies Syntaxin 3 and TRPML1 as critical for bacterial phagocytosis through focal exocytosis at pseudopodia.

This study compares the virulence mechanisms of four UPEC strains in macrophages and epithelial cells, showing that iron availability regulates their contrasting toxicities.

This study shows that T-cell cholesterol efflux via ABCA1/ABCG1 suppresses apoptosis and senescence, but paradoxically reduces atherosclerosis in middle-aged mice.

This study shows that Chromogranin A deficiency in mice prevents age-related insulin resistance and hypertension, with hypertension reversing spontaneously as mice age.

The paper shows that transmembrane helices are a conserved source of MHC-I and II epitopes, leading to over-presentation of membrane protein-derived peptides in immune responses.

This study uses FLIM to measure intracellular pH with high temporal resolution, revealing dynamic pH changes in the secretory pathway under drug treatments and during TNF transport.

This study shows that catestatin (CST) regulates the colonic mucus layer in IBD, with CST levels elevated in IBD patients and CST-KO mice showing increased mucus thickness.

This study shows that the anti-inflammatory peptide Catestatin blocks chemotaxis of monocytes and granulocytes to inflammatory chemokines like CCL2 and MIP-2.

This study shows that Catestatin increases hepatic glycogen synthesis in insulin-resistant mice by enhancing insulin signaling through the phosphoinositide 3-kinase-AKT pathway.

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

This paper introduces oxygen-independent chemogenetic protein tags that enhance fluorescence and enable prolonged live-cell imaging under oxygen-free conditions.