S. Mahajan

Autoaggregation in Streptococcus intermedius is driven by the Pel polysaccharide

This study identifies the Pel polysaccharide as a driver of autoaggregation in S. intermedius, linking it to biofilm formation and increased pathogenicity.

Comparative analysis of serological assays and sero-surveillance for SARS-CoV-2 exposure in US cattle

This study evaluates serological assays for SARS-CoV-2 in US cattle, finding no evidence of natural infection or transmission and highlighting issues with false positives in neutralization assays.

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

The paper identifies GIF/metallothionein-3 as a sulfane sulfur-binding protein that regulates zinc ion binding and release through a unique C-S-S-Zn structure.

Trafficking Machinery is Rapidly Primed to Facilitate Polarised IL-6 Secretion in Dendritic Cells

This study shows that LPS rapidly primes trafficking machinery in dendritic cells to enhance polarized IL-6 secretion through phosphorylation of VAMP3.

Cofilin-Driven Nuclear Deformation Drives Dendritic Cell Migration through the Extracellular Matrix

This study shows that cofilin-1 phosphorylation drives nuclear deformation and enhances dendritic cell migration through extracellular matrix.

Mechanisms of SARS-CoV-2 Inactivation using UVC Laser Radiation

This study investigates the inactivation of SARS-CoV-2 using UVC laser radiation and identifies mechanisms involving RNA damage and disruption of spike protein function.

Targeting the host protein G3BP1 for the discovery of novel antiviral inhibitors against Chikungunya virus

This study identifies seven small molecules that inhibit Chikungunya virus replication by targeting the G3BP1 protein's FGDF binding pocket.

SAM-dependent viral MTase inhibitors: herbacetin and caffeic acid phenethyl ester, structural insights into dengue MTase

The paper identifies herbacetin and caffeic acid phenethyl ester as inhibitors of dengue and chikungunya virus MTases, revealing their mechanism of action and antiviral efficacy.

Multi-excitation Raman Spectroscopy Complements Whole Genome Sequencing for Rapid Detection of Bacterial Infection and Resistance in WHO Priority Pathogens

This paper combines multi-excitation Raman spectroscopy with whole-genome sequencing to rapidly detect bacterial infections and resistance in WHO priority pathogens, achieving high accuracy in classification.

Whole-Genome Sequence of African Swine Fever Virus isolate from India provides insights into diversity and evolution

The paper reports the whole-genome sequence of an African swine fever virus isolate from India and compares it to other ASFV genomes to study genetic diversity and evolution.

Systemic infection of SARS-CoV-2 in free ranging Leopard (Panthera pardus fusca) in India

The paper reports SARS-CoV-2 infection in a free-ranging Indian leopard, confirming Delta variant infection and highlighting the need for wildlife screening.

Meeting experiments at the diffraction barrier: an in-silico widefield fluorescence microscopy

This paper introduces an in-silico widefield fluorescence microscopy technique that generates synthetic images from molecular simulations to enable cross-validation with experimental data.

Evolutionary jumps in bacterial GC content

The paper analyzes GC content evolution in bacteria using phylogenetic models, finding both gradual changes and evolutionary jumps in GC content across multiple bacterial groups.

TCRMatch: Predicting T-cell receptor specificity based on sequence similarity to previously characterized receptors

TCRMatch predicts T-cell receptor specificity by comparing sequence similarity to known epitope-specific receptors in the IEDB.

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

This study identifies immunodominant T-cell epitopes in SARS-CoV-2 spike antigen and shows pre-existing T-cell immunity in unexposed individuals, suggesting prior exposure to common viruses like Influenza and CMV.

Label-free and Multimodal Second Harmonic Generation Light Sheet Microscopy

This paper demonstrates a label-free SHG-LSM technique for 3D imaging of collagen and other harmonophores, combining SHG with light sheet microscopy for multimodal imaging.

Super-resolved polarisation-enhanced second harmonic generation for direct imaging of nanoscale changes in collagen architecture

This paper introduces a super-resolution SHG technique that achieves nanoscale imaging of collagen architecture without fluorescent labels, revealing previously unobservable structural changes.

Massive gene amplification on a recently formed Drosophila Y chromosome

The paper shows that the neo-Y chromosome of Drosophila miranda has gained over 3200 genes since its formation through tandem amplification, driven by sexual and meiotic conflict.