Neutrophil adhesion in brain capillaries contributes to cortical blood flow decreases and impaired memory function in a mouse model of Alzheimer’s disease
Jean C. Cruz Hernández, Oliver Bracko, Calvin J. Kersbergen, Victorine Muse, Mohammad Haft‐Javaherian, Maxime Berg, Laibaik Park, Lou Vinarcsik, Iryna Ivasyk, Daniel Rivera, Yiming Kang, Marta Cortés‐Canteli, Myriam Peyrounette, Vincent Doyeux, Amy F. Smith, , Chris B. Schaffer
This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.
Nature Neuroscience · Feb 11, 2019Peer-reviewedNeuroscience