Laibaik Park

This study uses scRNA-seq in a mouse hypertension model to identify early molecular changes in brain cells linked to neurovascular dysfunction and cognitive impairment.

This study shows that perimenopause increases Aβ aggregation and glial activation in specific hippocampal regions in female 5xFAD mice, but not cognitive deficits.

This study shows that inhibiting NOX2 reduces capillary stalling and inflammation in Alzheimer's mice, improving memory and blood flow.

This study identifies meningeal IL-17-producing T cells as a key driver of cognitive impairment in hypertension, showing their role in activating brain macrophages and suggesting therapeutic targets.

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.