Small-molecule control of super-Mendelian inheritance in gene drives
Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox, Shubhroz Gill, Alena L. Bishop, Garrett D. Scanlon, James A. Walker, Valentino Matteo Gantz, Amit Choudhary
The paper describes a gene-drive system in Drosophila controlled by an engineered Cas9 and a synthetic small molecule to enable chemical control of inheritance.
Cell Reports · Jun 1, 2020Peer-reviewedGenetics