A conjugation platform for CRISPR-Cas9 allows efficient β-cell engineering
Donghyun Lim, Vedagopuram Sreekanth, Kurt J. Cox, Benjamin K. Law, Bridget K. Wagner, Jeffrey M. Karp, Amit Choudhary
This paper introduces a CRISPR-Cas9 conjugation platform for multivalent display of molecules, enhancing genome editing precision and enabling β-cell engineering to secrete interleukin-10.
Nature Communications · Aug 13, 2020Peer-reviewedSynthetic Biology