The paper identifies shared molecular networks between common and rare variants associated with alcohol consumption, revealing genes involved in alcohol metabolism and comorbid psychiatric traits.

Alcoholism Clinical and Experimental Research · Jun 21, 2024Peer-reviewedGenetics

Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Sylvanus Toikumo, Mariela V. Jennings, Benjamin K. Pham, Hyunjoon Lee, Travis T. Mallard, Sevim B. Bianchi, John J. Meredith, Laura Vilar‐Ribó, Heng Xu, Alexander Samir Hatoum, Emma C. Johnson, Vanessa Pazdernik, Zeal Jinwala, Shreya Reddy Pakala, Brittany S. Leger, , Sandra Sanchez‐Roige

This study performs a multi-ancestry meta-analysis of tobacco use disorder using electronic health records, identifying 88 risk loci and 461 potential risk genes, and linking TUD to various health outcomes.

medRxiv · Mar 27, 2023 · PreprintGenetic & Genomic Medicine

HTT is a repressor of ABL activity required for APP induced axonal growth

Claire Marquilly, Germain U. Busto, Brittany S. Leger, Ana Boulanger, Edward Giniger, James A. Walker, Lee G. Fradkin, Jean‐Maurice Dura

The paper shows HTT represses ABL activity, which is necessary for axonal growth in Drosophila mushroom bodies.

PLoS Genetics · Jan 19, 2021Peer-reviewedNeuroscience

Small-molecule control of super-Mendelian inheritance in gene drives

Víctor López Del Amo, Brittany S. Leger, Kurt J. Cox, Shubhroz Gill, Alena L. Bishop, Garrett D. Scanlon, James A. Walker, Valentino Matteo Gantz, Amit Choudhary

The paper describes a gene-drive system in Drosophila controlled by an engineered Cas9 and a synthetic small molecule to enable chemical control of inheritance.

Cell Reports · Jun 1, 2020Peer-reviewedGenetics