Mechanism of K63-linked polyubiquitin recognition and cleavage by the BRCA1-A complex
Martina Foglizzo, Arindam Datta, Oksana Degtjarik, Hirunika Perera, Jordan Liburd, Upasana M. Sykora, Sri Ranjani Ganji, Gemma C. Wildsmith, Francesca Chandler, Lisa J. Campbell, Antonio N. Calabrese, Roger A. Greenberg, Elton Zeqiraj
The paper investigates how the BRCA1-A complex recognizes and cleaves K63-linked polyubiquitin chains, revealing structural and functional mechanisms involved in DNA damage response.
Nature Communications · Aug 11, 2026Peer-reviewedBiochemistry