Dolichol biosynthesis in yeast traces the expanded reaction pathway of higher eukaryotes
Matthew P. Wilson, Takfarinas Kentache, Charlotte R. Althoff, Isabelle Gerin, Shin‐Yi Yu, Marie Morel, Céline Schulz, Sahar Sabry, Jean Jacobs, Julie Graff, Geoffroy de Bettignies, Liliana Surmacz, William C. Sessa, Emile VAN SCHAFTINGEN, Gert Matthijs, , François Foulquier
This study identifies two yeast enzymes, Env9 and Tda5, that perform distinct steps in dolichol biosynthesis, replacing the dual role of DHRSX in humans.
bioRxiv · Apr 24, 2026 · PreprintBiochemistry