Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formation.
Arnas Petrauskas, Daniel L. Fortunati, Amanjot Singh, Arvind Reddy Kandi, Sai Shruti Pothapragada, Khushboo Agrawal, Joern Huelsmeier, Jens Hillebrand, Georgia Brown, Dhananjay Chaturvedi, Jongbo Lee, Chunghun Lim, Georg W. J. Auburger, K. VijayRaghavan, Mani Ramaswami, Baskar Bakthavachalu
This study investigates how structured and disordered regions of Ataxin-2 influence mRNP granule formation and neurodegeneration in Drosophila and human models.
PLoS Genetics · May 20, 2024Peer-reviewedNeuroscience