Mani Ramaswami

This study identifies Ataxin-2 as a regulator of the synaptonemal complex in Drosophila, showing its role in chromosome pairing during meiosis.

This study identifies Prefoldin 5 as a microtubule-associated protein that suppresses Tau-aggregation and neurotoxicity in Drosophila.

This study shows Ataxin-2 is required in Kenyon cells for mRNP granule assembly and appetitive long-term memory formation in Drosophila.

This study identifies Ataxin-2 as a regulator of meiotic entry in Drosophila by downregulating Dacapo, leading to timely premeiotic DNA replication and preventing genomic damage in oocytes.

This study investigates how structured and disordered regions of Ataxin-2 influence mRNP granule formation and neurodegeneration in Drosophila and human models.

The paper shows that local axonal translation of CaMKII mRNA, mediated by Mub and a 3UTR element, is essential for asymmetric CaMKII distribution and associative memory in Drosophila neurons.

This study shows that novel stimuli can override gustatory habituation in Drosophila by activating TH-positive neurons that inhibit GABAergic cells involved in habituation.

This study shows that the Ataxin-2 disordered region promotes Huntingtin protein aggregation and neurodegeneration in Drosophila HD models.

This study identifies Ataxin-2 target mRNAs and shows its structured and disordered domains regulate RNP granule formation and mRNA stability in Drosophila.

This paper explores the role of inhibitory engrams in perception and memory, showing they regulate behavior and memory storage through balanced neural activity.

This paper presents a genome-wide fosmid library of GFP-tagged Drosophila genes to study protein expression and localisation across developmental stages.