Julian Kwan

Angiopoietin-like protein 7 (ANGPTL7)-mediated effects on resident immune cells contribute to neurodegeneration in glaucomatous optic nerve head

This study shows ANGPTL7 affects immune cells in the optic nerve head, contributing to neurodegeneration in glaucoma, despite no effect on intraocular pressure.

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs

The paper identifies prion synaptotoxic pathways and inhibitory drugs using phosphoproteomic and transcriptomic data from prion-treated neurons.

Multi-modal comparison of molecular programs driving nurse cell death and clearance in Drosophila melanogaster oogenesis

The paper compares molecular programs in Drosophila nurse cell death and clearance under different conditions, identifying pathways and genes involved in apoptotic and non-apoptotic clearance mechanisms.

Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral

This study investigates immune regulation in symbiotic and aposymbiotic coral tissue using multiomic approaches, revealing compartmentalized immune suppression in specific cell types during symbiosis.

DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin

This study shows that DOT1L promotes the degradation of c-MYC and MML-1 transcription factors on chromatin, regulating their target genes and potentially offering new cancer treatment strategies.

A Complex Containing HNRNPA2B1 and N6-methyladenosine Modified Transcripts Mediates Actions of Toxic Tau Oligomers

This paper identifies a complex involving HNRNPA2B1, N6-methyladenosine modified transcripts, and toxic tau oligomers that mediates neurodegeneration.

Native KCC2 Interactome Reveals PACSIN1 As A Critical Regulator Of Synaptic Inhibition

The paper identifies PACSIN1 as a key negative regulator of KCC2 function through a native KCC2 interactome analysis in the mouse brain.