An N-acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson s disease
Francesca Palese, Carmela Giachino, Sylvie Syan, Giuliana Ottonello, Giulia Sciandrone, Carolina Filipponi, Michele Lai, Andrea Armirotti, Michela Deleidi, Chiara Zurzolo
This study identifies NAPEs as regulators of LRRK2 and lysosomal function in Parkinson's disease, showing that boosting NAPEs reduces LRRK2 activity and clears alpha-synuclein aggregates.
bioRxiv · Jun 2, 2026 · PreprintCell Biology