Michele Lai

This paper tests the neuroprotective effects of MNP-021 against diabetes-induced glucotoxicity and neuroinflammation in neurons and glial cells, finding it restores glucose handling, mitochondrial function, and pro-resolving signaling.

This study shows HSV-1 uses peroxisomal metabolism and lipid pathways in human neurons to support its replication and suggests this may contribute to neuronal damage in Alzheimer's disease.

This study identifies NAPEs as regulators of LRRK2 and lysosomal function in Parkinson's disease, showing that boosting NAPEs reduces LRRK2 activity and clears alpha-synuclein aggregates.

This study shows that inhibiting NAAA reduces SARS-CoV-2 replication in human lung tissue and suppresses NF-kappaB signaling.

This paper presents a transfection-free method for delivering Cas9:gRNA ribonucleoprotein using gold nanoparticles, achieving effective gene editing in human melanoma cells.