Chiara Zurzolo

The paper identifies and characterizes intercellular connections in the developing cerebellum, suggesting a potential new mode of communication during neural development.

This study shows bidirectional mitochondrial transfer via tunneling nanotubes between glioblastoma cells and astrocytes, both in vitro and in vivo, and highlights their role in tumor microenvironment interactions.

This study identifies NAPEs as regulators of LRRK2 and lysosomal function in Parkinson's disease, showing that boosting NAPEs reduces LRRK2 activity and clears alpha-synuclein aggregates.

This study shows that α-synuclein aggregates cause mitochondrial damage and activate innate immunity, leading to neuron-microglia communication via TNTs and promoting disease progression in Synucleinopathies.

The paper shows that neuronal autophagy failure leads to α-synuclein aggregate transfer to microglia, which then degrade them more efficiently.

This study identifies N-Cadherin and its effectors in regulating tunneling nanotube formation and function in neuronal-like cells.

This study shows that p.A53T-α-Synuclein astrocytes from Parkinson's patients impair proteostasis, leading to neurodegeneration and Lewy-like pathology in co-cultured neurons.

CellWalker provides a modular, open-source pipeline for segmentation and morphological analysis of microscopy images using deep learning and Blender tools.

The paper uses 3D reconstruction and deep learning to reveal intercellular connections between developing granule cells in the cerebellar EGL, showing a continuum of proliferative and migratory events.

This study uses correlative light and cryo-electron microscopy to characterize tunneling nanotubes, revealing their structural composition and distinction from filopodia.