Author

Carmela Giachino

InsermORCID 0000-0003-3650-8677Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Michela DeleidiiD· 3 shared Marika MearelliiD· 2 shared Andrea ArmirottiiD· 1 shared Bianca MarchettiiD· 1 shared Carolina FilipponiiD· 1 shared Cataldo TiroloiD· 1 shared Chiara ZurzoloiD· 1 shared Christin WeisslederiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Michela DeleidiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintJun 2, 2026

An N-acylphosphatidylethanolamine-LRRK2 axis controls lysosomal homeostasis in Parkinson s disease

Francesca Palese, Carmela Giachino, Sylvie Syan…·Chiara Zurzolo

This study identifies NAPEs as regulators of LRRK2 and lysosomal function in Parkinson's disease, showing that boosting NAPEs reduces LRRK2 activity and clears alpha-synuclein aggregates.

DOI 10.64898/2026.03.19.712902

humanproteomics

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NeuroscienceGliaPeer-reviewedSep 1, 2025

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC- Derived Microglia and Modulates Glial-Neuronal Crosstalk

Marika Mearelli, Insa Hirschberg, Christin Weissleder…·Michela Deleidi

This study investigates how C9orf72 repeat expansion affects metabolism in human iPSC-derived microglia and its impact on glial-neuronal interactions in ALS.

3 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintSep 1, 2022

LRRK2-G2019S SYNERGIZES WITH AGEING AND LOW-GRADE INFLAMMATION TO PROMOTE GUT AND PERIPHERAL IMMUNE CELL ACTIVATION THAT PRECEDE NIGROSTRIATAL DEGENERATION

Carmela Giachino, Cataldo Tirolo, Salvatore Caniglia…·Bianca Marchetti

This study shows that LRRK2 G2019S mutation interacts with low-grade inflammation and aging to promote gut and peripheral immune activation before nigrostriatal degeneration in mice.

3 citations

mouseexperimental assay

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